About 90 people with breathing issues left La Loche on Wednesday and will be staying in Regina.
The communities of Deschambault Lake, Clearwater River Dene Nation, Turnor Lake and Birch Narrows have self-evacuated.
There are 264 evacuees from Patuanak and English River in North Battleford, as well as evacuees from Dillon, Michel Village and St. George’s Hill in Lloydminster.
There are currently 20 wildfires burning in northern Saskatchewan, including eight that are not contained.
The Saskatchewan Public Safety Agency is expected to update the situation late Thursday morning during a media briefing.